Tacrolimus-13C,D2 (FK506-13C,D2) is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds toFK506 binding protein (FKBP)to form a complex. Tacrolimus inhibitscalcineurinphosphatase, which inhibits T-lymphocyte signal transduction andIL-2transcription. Immunosuppressive properties^[1].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

807.02

Solid

C₄₃¹³CH₆₇D₂NO₁₂

1356841-89-8

他克莫司 13C,d2

Room temperature in continental US; may vary elsewhere.