他氟前列素（游离酸）（AFP-172）是他氟前列素的一种活性代谢形式，是一种选择性前列腺素 FP 受体激动剂。
| Cas No. | 209860-88-8 |
| 别名 | 他氟前列素酸,AFP-172 |
| Canonical SMILES | O[C@@H](C[C@@H](O)[C@@H]1/C=C/C(F)(F)COC2=CC=CC=C2)[C@@H]1C/C=C\CCCC(O)=O |
| 分子式 | C22H28F2O5 |
| 分子量 | 410.5 |
| 溶解度 | DMF: 30 mg/ml,DSMO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 3 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile. Tafluprost is a 2-series, 16-phenoxy analog of PGF2α with the 15,15-difluoro substitution. Tafluprost (free acid) is a very potent FP receptor agonist, with a Ki of 0.4 nM. The ester prodrug forms of tafluprost are also potent ocular hypotensives in monkeys. |
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