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Lercanidipine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lercanidipine hydrochloride图片
CAS NO:132866-11-6
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议
100mg电议
200mg电议

产品介绍
Lercanidipine hydrochloride 是一种亲脂性第三代二氢吡啶-钙通道阻滞剂 (DHP-CCB)。
Cas No.132866-11-6
别名盐酸乐卡地平
化学名3-(1-((3,3-diphenylpropyl)(methyl)amino)-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
Canonical SMILESCC(N1)=C(C(OC)=O)C(C(C(OC(C)(CN(CCC(C2=CC=CC=C2)C3=CC=CC=C3)C)C)=O)=C1C)C4=CC(N(=O)=O)=CC=C4.Cl
分子式C36H42ClN3O6
分子量648.19
溶解度DMF: 25mg/mL,DMF:PBS (pH 7.2) (1:2): 0.3mg/mL,DMSO: 15mg/mL,Ethanol: 2mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lercanidipine hydrochloride is a calcium channel blocker of the dihydropyridine class.Target: Calcium ChannelLercanidipine is a calcium channel blocker of the dihydropyridine class, which works by relaxing and opening the blood vessels allowing the blood to circulate more freely around the body. Lercanidipine was effective and well-tolerated in patients with mild-to-moderate hypertension in the daily practice. The effectiveness and safety of the drug were independent of the degree of cardiovascular risk [1, 2].

References:
[1]. Barrios, V., et al., Lercanidipine is an effective and well tolerated antihypertensive drug regardless the cardiovascular risk profile: The LAURA study. Int J Clin Pract, 2006. 60(11): p. 1364-70.
[2]. Burnier, M., M. Pruijm, and G. Wuerzner, Treatment of essential hypertension with calcium channel blockers: what is the place of lercanidipine Expert Opin Drug Metab Toxicol, 2009. 5(8): p. 981-7.