SY-5609 (SY5609; CDK7-IN-3) is a novel, selective, non-covalent and orally bioavailable CDK7 inhibitor (KD = 0.059 nM) with anticancer activity. SY-5609 shows high selectivity for CDK7 over CDK2 (K_i=2600 nM), CDK9 (K_i=960 nM), CDK12 (K_i=870 nM). CDK7 has emerged as an exciting target in oncology due to its roles in two important processes that are misregulated in cancer cells: cell cycle and transcription. SY-5609 displays potent inhibition of CDK7 in cells and demonstrates strong efficacy in mouse xenograft models when dosed as low as 2 mg/kg.

纯度：≥98%

CAS：2417302-07-7