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Trimethylamine N-oxide-d9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Trimethylamine N-oxide-d9图片
CAS NO:1161070-49-0
包装:5mg
市场价:7800元

产品名称
三甲胺N-氧化物 d9
产品介绍
Trimethylamine N-oxide-d9 是 Trimethylamine N-oxide 的氘代物。Trimethylamine N-oxide 是一种膳食胆碱和其他含三甲胺营养素的肠道微生物依赖性代谢产物。Trimethylamine N-oxide 通过激活ROS/NLRP3炎性体诱导炎症。Trimethylamine N-oxide 还通过激活TGF-β/smad2信号通路来加速成纤维细胞的分化并诱导心脏纤维化。
生物活性

Trimethylamine N-oxide-d9 is the deuterium labeled Trimethylamine N-oxide. Trimethylamine N-oxide is a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients. Trimethylamine N-oxide induces inflammation by activating theROS/NLRP3 inflammasome. Trimethylamine N-oxide also accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis by activating theTGF-β/smad2signaling pathway[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

84.17

性状

Solid

Formula

C3D9NO

CAS 号

1161070-49-0

中文名称

三甲胺N-氧化物 d9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
In solvent-80°C6 months
-20°C1 month