5-Fluorouracil-d1 (5-FU-d1) is the deuterium labeled 5-Fluorouracil. 5-Fluorouracil (5-FU) is an analogue of uracil and a potent antitumor agent. 5-Fluorouracil affectspyrimidine synthesisby inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. 5-Fluorouracil inducesapoptosisand can be used as a chemical sensitizer^[1][2]. 5-Fluorouracil also inhibitsHIV^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

131.08

C₄H₂DFN₂O₂

90344-84-6

5-氟脲嘧啶 d1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.