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Gabexate Mesylate(Megacert Arodate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gabexate Mesylate(Megacert Arodate)图片
CAS NO:56974-61-9
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)417.48
FormulaC16H23N3O4.CH4O3S
CAS No.56974-61-9
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 83 mg/mL (198.8 mM)
Water: 12 mg/mL (28.7 mM)
Ethanol: 83 mg/mL (198.8 mM)
Other info

Chemical Name: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate

InChi Key: DNTNDFLIKUKKOC-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)

SMILES Code: O=C(OCC)C1=CC=C(OC(CCCCCNC(N)=N)=O)C=C1.OS(=O)(C)=O

Synonyms

Megacert; Mesyl Gabexate; gabexate mesilate; Arodate; Megacart; Gabexate; Gabexate mesylate; Arodate.

实验参考方法
In Vitro

In vitro activity: Gabexate mesylate is also found to inhibit cNOS and iNOS, with Ki values of 150μM and 5mM. It up-regulates iNOS gene expression. In addition, gabexate mesylate inhibits the LPS/IFNγ-induced NO production with EC50 value of 250μM


Cell Assay: Gabexate mesylate inhibits competitively constitutive and inducible NO synthase (cNOS and iNOS, respectively), with Kivalues of 1.0×10 4M and 5.0×10 3M, respectively, at pH 7.4 and 37.0°C. gabexate mesylate increases iNOS mRNA expression in rat C6 glioma cells, as induced byE. colilipopolysaccharide plus interferon-γ. Gabexate mesylate inhibits dose-dependently nitrite production (i.e. NO release) in rat C6 glioma cells, as induced byE. colilipopolysaccharide plus interferon-γ

In Vivo
Animal model
Formulation & Dosage
References

Biochem Biophys Res Commun. 1998 May 19;246(2):453-6.