Latrunculin B, an antimicrobial marine alkaloid, is anactin polymerizationinhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis. Antifungal and antiprotozoal activity^[1][2].

Latrunculin B displays growth inhibition of HeLa cells with an IC₅₀value of 1.4 μM^[1].
Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na⁺current, L-type Ca²⁺current, Na⁺/Ca²⁺exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K⁺current and ultra-rapid delayed rectifier K⁺current, but increases the delayed rectifier K⁺current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca²⁺transient and sarcoplasmic reticulum Ca²⁺content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity^[2].

395.51

Oil

C₂₀H₂₉NO₅S

76343-94-7

红海海绵素 B

Red Sea sponge

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