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Aprotinin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aprotinin图片
CAS NO:9087-70-1
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
Aprotinin is a novel and potent small protein serine protease / bovine pancreatic trypsin inhibitor (BPTI) with antifibrinolytic activity. It inhibits trypsin and chymotrypsin with Kis of 0.06 pM and 9 nM, respectively. Aprotinin is used to reduce perioperative blood loss and transfusion. The use of aprotinin did not significantly increase the risk of renal failure or the need for postoperative renal replacement despite an increase in the proportion of patients who had a doubling of serum creatinine levels. The adjudication of death did not identify renal failure as contributing to or causing death associated with aprotinin use. A Meta analysis by Brown and colleagues showed a nonsignificant relative risk of renal failure with high-dose aprotinin.
理化性质和储存条件
Molecular Weight (MW)6511.51
FormulaC284H432N84O79S7
CAS No.9087-70-1
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 100 mg/mL (15.4 mM)
Water:<1 mg/mL
Ethanol:<1 mg/mL
Other info
SMILES: OC([C@@H](NC(CNC(CNC([C@@H](N1)CSSC[C@H](NC([C@@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H](CCCNC(N)=N)N[H])=O)=O)CC(O)=O)=O)CC3=CC=CC=C3)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(O)=O)C(N4CCC[C@H]4C(N5CCC[C@H]5C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(NCC(N6CCC[C@H]6C(N[C
InChi Code: InChI=1S/C284H434N84O79S7/c1-21-144(9)222-271(439)337-174(68-46-105-309-282(300)301)239(407)340-187(120-160-77-85-164(374)86-78-160)251(419)341-185(116-156-55-29-24-30-56-156)250(418)342-188(121-161-79-87-165(375)88-80-161)252(420)346-191(123-208(291
InChi Key: RWLBZZCCAZDWSE-LPYSRVMUSA-N
SynonymsBPTI; Aprotinin; Bovine Pancreatic Trypsin Inhibitor;