您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Capreomycin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Capreomycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:11003-38-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Capreomycin 是一种大环肽类抗生素 (antibiotic)。Capreomycin 可用于抗多耐药性结核分枝杆菌的研究。Capreomycin 可抑制分枝杆菌核糖体转译中苯丙氨酸的合成。
生物活性

Capreomycin is a macrocyclic peptideantibiotic. Capreomycin can be used for anti-multidrug-resistant-tuberculosis research. Capreomycin can inhibit phenylalanine synthesis in in mycobacterial ribosomes translation[1][2]

IC50& Target

Aminoglycoside

 

体内研究
(In Vivo)

Capreomycin (1.4, 7.2, and 14.5 mg/kg for inhale; 20 mg/kg for i.m.; 4 weeks) decreases the wet lung weight and lowers bacterial burden in the lungs of infected guinea pigs[2].

Animal Model:Male guinea pigs [836 ± 162.3 g; infected via the respiratory route with nebulized suspensions 2 × 105CFU/mL ofMycobacterium tuberculosis(strain H37Rv)][2]
Dosage:1.4, 7.2, and 14.5 mg/kg for inhale; 20 mg/kg for i.m.
Administration:Inhaling or i.m.; 4 weeks
Result:Significantly decreased the wet lung weight at 14.5 mg/kg, and smaller than receiving 1.4 mg/kg group and controls.
Significantly lowered bacterial burden in the lungs (3.52 ± 0.20 CFU/mL; P< 0.05) at 14.5 mg/kg than controls (4.58 ± 0.20 CFU/mL) and at 1.4 and 7.2 mg/kg (4.02 ± 0.32 and 4.01 ± 0.29 CFU/mL, respectively).
Clinical Trial
CAS 号

11003-38-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.