CAS NO: | 39831-55-5 |
包装 | 价格(元) |
10 mM * 1 mL in Water | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
10 g | 电议 |
50 g | 电议 |
生物活性 | Amikacin disulfate (BAY 41-6551 dissulfate) is anaminoglycosideantibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against mostGram-negative bacteriaincludinggentamicin- andtobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptibleNocardiaandnontuberculous mycobacteria[1][2]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused byNocardia asteroides,Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is,M. chelonaeandM. fortuitumi)[1]. | ||||||||||||||||
体内研究 (In Vivo) | Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3].
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Clinical Trial | |||||||||||||||||
分子量 | 781.76 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H47N5O21S2 | ||||||||||||||||
CAS 号 | 39831-55-5 | ||||||||||||||||
中文名称 | 阿米卡星硫酸盐;丁胺卡那霉素硫酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 100 mg/mL(127.92 mM;Need ultrasonic) DMSO : 1 mg/mL(1.28 mM;ultrasonic and warming and heat to 80℃) 配制储备液
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