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Amikacin disulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Amikacin disulfate图片
CAS NO:39831-55-5
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
500mg电议
1 g电议
5 g电议
10 g电议
50 g电议

产品名称
阿米卡星硫酸盐
BAY 41-6551 disulfate
产品介绍
Amikacin disulfate (BAY 41-6551 disulfate) 是一种氨基糖苷类抗生素,也是一种卡那霉素的半合成类似物。Amikacin disulfate 具有杀菌作用,直接作用于 30S 和 50S 细菌核糖体亚基,可抑制蛋白质合成。Amikacin disulfate 对大多数革兰氏阴性细菌 (Gram-negative bacteria) (包括庆大霉素和妥布霉素抗性菌株) 非常有效。Amikacin disulfate 还抑制易感诺卡氏菌和非结核分枝杆菌引起的感染。
生物活性

Amikacin disulfate (BAY 41-6551 dissulfate) is anaminoglycosideantibiotic and a semisynthetic analog of kanamycin. Amikacin disulfate is bactericidal, acting directly on the 30S and 50S bacerial ribosomal subunits to inhibit protein synthesis. Amikacin disulfate is very active against mostGram-negative bacteriaincludinggentamicin- andtobramycin-resistant strains. Amikacin disulfate also inhibits the infections caused by susceptibleNocardiaandnontuberculous mycobacteria[1][2].

IC50& Target

Aminoglycoside

 

体外研究
(In Vitro)

Amikacin offers definite advantages for treating infections caused by organisms resistant to other aminoglycosides. Amikaci is affected by relatively few arninoglycoside-modifying enzymes. Amikacin is useful in the treatment of infections caused byNocardia asteroides,Mycobacterium avium-intracellulare, and certain species of "rapid-growing" mycobacteria (that is,M. chelonaeandM. fortuitumi)[1].
Amikacin (100-1500 μM) causes a reliable dose-dependent loss of lateral line zebrafish hair cells with a LD50value of 453 μM[3].

体内研究
(In Vivo)

Amikacin (320 mg/kg; subcutaneous injection; daily; for 10 days; male Fischer rats) treatment increases the chance of serious hearing loss in rats in vivo[3].

Animal Model:Male Fischer 344 rats (40-50-day-old)[3]
Dosage:320 mg/kg
Administration:Subcutaneous injection; daily; for 10 days
Result:Induced hearing loss in rats.
Clinical Trial
分子量

781.76

性状

Solid

Formula

C22H47N5O21S2

CAS 号

39831-55-5

中文名称

阿米卡星硫酸盐;丁胺卡那霉素硫酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 100 mg/mL(127.92 mM;Need ultrasonic)

DMSO : 1 mg/mL(1.28 mM;ultrasonic and warming and heat to 80℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM1.2792 mL6.3958 mL12.7916 mL
5 mM0.2558 mL1.2792 mL2.5583 mL
10 mM0.1279 mL0.6396 mL1.2792 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 50 mg/mL (63.96 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。