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Bekanamycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bekanamycin图片
CAS NO:4696-76-8
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
100mg电议
200mg电议
500mg电议

产品名称
卡那霉素
Kanamycin B
产品介绍
Bekanamycin (Kanamycin B) 是一种氨基糖苷类抗生素,提取自Streptomyces kanamyceticus,抑制一系列革兰氏阳性和阴性细菌。
生物活性

Bekanamycin (Kanamycin B) is anaminoglycosideantibiotic produced byStreptomyces kanamyceticus, against an array of Gram-positive and Gram-negativebacterialstrain[1][2].

IC50& Target

Aminoglycoside

 

体外研究
(In Vitro)

Bekanamycin (Kanamycin B) is a precursor for semisynthetic antibiotics such as Arbekacin and Dibekacin and is generally extracted from the broth ofS. kanamyceticus[2].
Bekanamycin (Kanamycin B) in a concentration-dependent fashion reduces reversibly the quantal content of the end-plate potentials while it has no observable effect on the configuration of the extracellularly recorded presynaptic action potential. The reduction in evoked transmitter release produced by Bekanamycin could be antagonized either by increasing the external calcium concentration or by drugs like the aminopyridines which are to greatly enhance transmitter release from motor nerve terminals. Bekanamycin exerts potent inhibitory effects on transmitter release probably by interfering with the influx of calcium that occurs during depolarization of motor nerve terminals[3].

分子量

483.51

性状

Solid

Formula

C18H37N5O10

CAS 号

4696-76-8

中文名称

卡那霉素B杂质3

结构分类
  • Antibiotics
  • Other Antibiotics
来源

Streptomyces kanamyceticus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

H2O : ≥ 100 mg/mL(206.82 mM)

DMSO : 1 mg/mL(2.07 mM;ultrasonic and warming and heat to 80℃)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.0682 mL10.3410 mL20.6821 mL
5 mM0.4136 mL2.0682 mL4.1364 mL
10 mM0.2068 mL1.0341 mL2.0682 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 25 mg/mL (51.71 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。