Paromomycin Sulfate

立即咨询

Paromomycin Sulfate

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1263-89-4

包装与价格：

包装	价格(元)
10 mM * 1 mL in Water	电议
500mg	电议
1 g	电议
5 g	电议
10 g	电议

产品名称

硫酸巴龙霉素
Aminosidine sulfate

产品介绍

Paromomycin (Aminosidine) sulfate 是一种的广谱氨基糖苷类抗生素 (antibiotic)，具有杀螨杀菌作用，是新霉素 (HY-B0470) 衍生物。Paromomycin sulfate 通过与细菌 30S 核糖体 A 位点的 RNA 寡核苷酸特异性结合，使 mRNA 的翻译提前终止，并抑制蛋白质合成。Paromomycin sulfate 可用于细菌和寄生虫感染的研究。

生物活性

Paromomycin (Aminosidine) sulfate, a neomycin (HY-B0470) derivative, is a broad spectrumaminoglycosideantibioticwith amebicidal and bactericidal effects. Paromomycin sulfate prematures termination of translation of mRNA and inhibits protein synthesis by specifically binds to the RNA oligonucleotide at the A site ofbacterial30S ribosomes. Paromomycin sulfate can be used for the research ofbacterialand parasitic infections^[1]^[2]^[3].

IC₅₀& Target

Aminoglycoside

Amebae

体外研究
(In Vitro)

Paromomycin sulfate (500 μg/ml) reduces intracellular parasitic forms by 97.2% compared to control in Caco-2 cells and reduces the percentage of intracellularC. parvumforms by 99.5% in HCT-8 cells^[2].

体内研究
(In Vivo)

Paromomycin sulfate (oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection) reduces the number of oocyst per gram of feces and intestine. It shows minimal focal inflammation in only 20% of the sections at 50 mg/kg from the intestines of mice infected withC. parvumand only 10% of focal inflammation at 200 mg/kg^[1].

Animal Model:	Male Swiss albino mice^[1]
Dosage:	50 mg/kg-200 mg/kg
Administration:	Oral gavage; 50 mg/kg-200 mg/kg; once daily; for five consecutive days two weeks post infection
Result:	Was against cryptosporidiosis in vivo.

Clinical Trial

分子量

713.71

性状

Solid

Formula

C₂₃H₄₇N₅O₁₈S

CAS 号

1263-89-4

中文名称

硫酸新霉素杂质E

结构分类

Antibiotics
Other Antibiotics

来源

Streptomyces rimosus NRRL 2455

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : 100 mg/mL(140.11 mM;ultrasonic and warming and heat to 80℃)

Ethanol : 1 mg/mL(1.40 mM;Need ultrasonic)

DMSO : 1 mg/mL(1.40 mM;ultrasonic and warming and heat to 80℃)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	1.4011 mL	7.0056 mL	14.0113 mL
5 mM	0.2802 mL	1.4011 mL	2.8023 mL
10 mM	0.1401 mL	0.7006 mL	1.4011 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (140.11 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。