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Azido-PEG9-amine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Azido-PEG9-amine图片
CAS NO:1207714-69-9
包装与价格：
包装价格(元)
100mg电议
250mg电议

产品介绍
Azido-PEG9-amine 是一种不可降解 (non-cleavable) 的 9 单元 PEG-ADC 连接物，用于抗体偶联药物 (ADC) 的合成。Azido-PEG9-amine 也是一种基于 PEG 的 PROTAC linker，可用于 PROTAC 的合成。
Cas No.1207714-69-9
分子式C20H42N4O9
分子量482.57
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Azido-PEG9-amine is a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG9-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.