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AEBSF HCl
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AEBSF HCl图片
CAS NO:30827-99-7
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)239.69
FormulaC8H11ClFNO2S
CAS No.30827-99-7
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 47 mg/mL (196.1 mM)
Water: 20 mg/mL (83.4 mM)
Ethanol: 47 mg/mL (196.1 mM)
Other info

Chemical Name: 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride

InChi Key: WRDABNWSWOHGMS-UHFFFAOYSA-N

InChi Code: InChI=1S/C8H10FNO2S.ClH/c9-13(11,12)8-3-1-7(2-4-8)5-6-10;/h1-4H,5-6,10H2;1H

SMILES Code: O=S(C1=CC=C(CCN)C=C1)(F)=O.[H]Cl

Synonyms

AEBSF HCl; AEBSF hydrochloride;

实验参考方法
In Vitro

In vitro activity: AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern


Cell Assay: AEBSF was found to inhibit Aβ production in various cell lines. In K293 cells transfected with βAPP695 (K695sw), AEBSF showed dose-dependent reduction of Aβ with the IC50 value of about 1 mM. In HS695 and SKN695 cells transfected with wild-type APP695, AEBSF showed inhibition effect with IC50 value of about 300 μM. AEBSF was also found to increase α-cleavege and inhibit β- cleavage.

In VivoAEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.
Animal modelMice infected by a lethal T. Gondii
Formulation & DosageFormulated in 0.89% saline; 76.8 mg/kg daily; i.p. injection
References

J Leukoc Biol. 1996 Sep;60(3):328-36; J Antimicrob Chemother. 2002 May;49(5):871-4; Contraception. 2011 Dec;84(6):642-8.