您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Grepafloxacin hydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Grepafloxacin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Grepafloxacin hydrochloride图片
CAS NO:161967-81-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
OPC-17116 hydrochloride
dl-Grepafloxacin hydrochloride
产品介绍
Grepafloxacin (OPC-17116) hydrochloride 是一种口服活性氟喹诺酮类抗生素 (antibiotic),对包括肺炎链球菌在内的社区获得性呼吸道病原体具有有效活性。Grepafloxacin hydrochloride 具有较高的组织渗透性和良好的药效学特性。
生物活性

Grepafloxacin (OPC-17116) hydrochloride is an oral actively fluoroquinoloneantibioticwith potent activity against community-acquired respiratory pathogens includingStreptococcus pneumonia. Grepafloxacin hydrochloride has high tissue penetration and a promising pharmacodynamic profile[1][2][3][4].

IC50& Target

Quinolone

 

体外研究
(In Vitro)

Grepafloxacin (OPC-17116; 0-1 mg/L; 14-21 d) hydrochloride has antibiotic activity with a MIC value of ≤ 0.006 mg/L forE. colistrain[1].
Grepafloxacin (0-1 mg/L; 3 h) hydrochloride has antimicrobial activity against mycobacteria in macrophages with a MIC value of 0.5 mg/L forM. avium[1].
Grepafloxacin hydrochloride exhibits potent in vitro antibacterial activity against Gram-positive bacteria such as Streptococcus pneumoniae and high in vivo efficacy on the experimental systemic infections caused by the Gram-positive and -negative bacteria tested[4].

体内研究
(In Vivo)

Grepafloxacin (OPC-17116; 200 mg/kg; p.o.; Balb/c mice) hydrochloride displays good safety profile in terms of phototoxicity[2].
Grepafloxacin (25-200 mg/kg; p.o.; 5 days/week for 4 weeks; female C57BL6/J-Lyst bg-J/ mice/beige mice) hydrochloride has modest activities in both intranasal (IN) infection and intravenous (IV)Mycobacterium aviuminfection models[3].

分子量

395.86

性状

Solid

Formula

C19H23ClFN3O3

CAS 号

161967-81-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : ≥ 13.33 mg/mL(33.67 mM)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.5261 mL12.6307 mL25.2615 mL
5 mM0.5052 mL2.5261 mL5.0523 mL
10 mM0.2526 mL1.2631 mL2.5261 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。