CAS NO: | 186826-86-8 |
包装 | 价格(元) |
50mg | 电议 |
100mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acutebacterialsinusitis, acutebacterialexacerbations of chronic bronchitis, and community-acquired pneumonia[1][2]. | ||||||||||||||||
IC50& Target |
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体外研究 (In Vitro) | The in vitro activities of Moxifloxacin Hydrochloride (BAY 12-8039) and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected byL. monocytogenesEGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation[3]. | ||||||||||||||||
体内研究 (In Vivo) | Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic[4].
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Clinical Trial | |||||||||||||||||
分子量 | 437.89 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C21H25ClFN3O4 | ||||||||||||||||
CAS 号 | 186826-86-8 | ||||||||||||||||
中文名称 | 盐酸莫西沙星;莫西沙星盐酸盐 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : ≥ 31 mg/mL(70.79 mM) H2O : 16.67 mg/mL(38.07 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. 配制储备液
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以下溶剂前显示的百
*以上所有助溶剂都可在本网站选购。 |