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Moxifloxacin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Moxifloxacin hydrochloride图片
CAS NO:186826-86-8
包装与价格:
包装价格(元)
50mg电议
100mg电议
500mg电议
1 g电议
5 g电议

产品名称
莫西沙星盐酸盐
BAY 12-8039
产品介绍
Moxifloxacin Hydrochloride (BAY 12-8039) 是一种口服有效的 8-甲氧基喹诺酮类抗菌药物,用于急性细菌性鼻窦炎,慢性支气管炎的急性细菌性加重和感染性肺炎的研究。
生物活性

Moxifloxacin Hydrochloride (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acutebacterialsinusitis, acutebacterialexacerbations of chronic bronchitis, and community-acquired pneumonia[1][2].

IC50& Target

Quinolone

 

体外研究
(In Vitro)

The in vitro activities of Moxifloxacin Hydrochloride (BAY 12-8039) and Amoxicillin are compared by time-kill curve and inhibition of intracellular growth experiments by using a model of bone marrow-derived mouse macrophages infected byL. monocytogenesEGDe. Moxifloxacin acts much more rapidly, beginning to exert its effects in the first 3 h and achieving complete broth sterilization within 24 h of incubation. Moxifloxacin appears to have a protective effect against macrophage lysis, as many cells are still viable after 24 h of incubation[3].

体内研究
(In Vivo)

Moxifloxacin (BAY 12-8039; 12 mg/kg; intravenous injection; once-three times per day; for 7 days; white male Wistar rats) treatment every 8 hours is accompanied by longer survival. Tissue cultures 30 hours after bacterial challenge shows considerably less bacterial overgrowth in the spleens and lungs of moxifloxacin-treated than in salinetreated animals and without being toxic[4].

Animal Model:144 white male Wistar rats (18-22 weeks; 300-400 g) infectedStenotrophomonas maltophilia[4]
Dosage:12 mg/kg
Administration:Intravenous injection; once per day, twice per day, three times per day; for 7 days
Result:Showed considerably less bacterial overgrowth in the spleens and lungs and without being toxic.
Clinical Trial
分子量

437.89

性状

Solid

Formula

C21H25ClFN3O4

CAS 号

186826-86-8

中文名称

盐酸莫西沙星;莫西沙星盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

DMSO : ≥ 31 mg/mL(70.79 mM)

H2O : 16.67 mg/mL(38.07 mM;Need ultrasonic)

*"≥" means soluble, but saturation unknown.

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.2837 mL11.4184 mL22.8368 mL
5 mM0.4567 mL2.2837 mL4.5674 mL
10 mM0.2284 mL1.1418 mL2.2837 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂:

——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂: PBS

    Solubility: 4 mg/mL (9.13 mM); Clear solution; Need ultrasonic and warming and heat to 60℃

*以上所有助溶剂都可在本网站选购。