CAS NO: | 389-08-2 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
500mg | 电议 |
5 g | 电议 |
10 g | 电议 |
50 g | 电议 |
生物活性 | Nalidixic acid, aquinoloneantibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit ofDNA gyraseandtopoisomeraseIVand reversibly blocks DNA replication in susceptible bacteria[1]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Nalidixic acid is against a variety of microorganisms, it is against withEscherichia coli,Pasteurella spp.,Klebsiella pneuiiioniae,Aerobacter aeroyenes,Proteus spp.,Salmonella spp.,Shigella spp.andBrucella spp.with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1]. | ||||||||||||||||
体内研究 (In Vivo) | The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused byE. coli,A. aerobacter,Proteus mirabilis,Shigella fkxneri, the ED50values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively[1].The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg, and subcutaneous, 500 mg/kg[1]. | ||||||||||||||||
分子量 | 232.24 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C12H12N2O3 | ||||||||||||||||
CAS 号 | 389-08-2 | ||||||||||||||||
中文名称 | 萘啶酸 | ||||||||||||||||
结构分类 |
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来源 | Streptomyces sp. | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 6 mg/mL(25.84 mM;Need ultrasonic) H2O : 5 mg/mL(21.53 mM;ultrasonic and warming and heat to 80℃) 配制储备液
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