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Enrofloxacin monohydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Enrofloxacin monohydrochloride图片
CAS NO:93106-59-3
包装与价格:
包装价格(元)
10 mM * 1 mL in Water电议
500mg电议
5 g电议
10 g电议
50 g电议

产品名称
恩诺沙星单盐酸盐
BAY Vp 2674 monohydrochloride
PD160788 monohydrochloride
产品介绍
Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) 是一种有效的抗生素,作用于Mycoplasma bovis,MIC90为 0.312 μg/ mL。Enrofloxacin monohydrochloride 具有抗牛痘病毒的活性。
生物活性

Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effectiveantibioticwith an MIC90of 0.312 μg/mL forMycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

IC50& Target

Quinolone

 

体外研究
(In Vitro)

Mycoplasma bovisis a worldwide pathogen, causative agent of pneumonia, mastitis, arthritis, and a variety of other symptoms in cattle. The antibiotic susceptibility profiles of the Hungarian strains are consistent within the tested group of fluoroquinolones. Three isolates (MYC44, MYC45 and MYC46) have high MIC values (≥10 μg/mL) to Enrofloxacin, while the rest of the strains are inhibited by Enrofloxacin with MICs ≤0.312 or 0.625 μg/mL[1].

体内研究
(In Vivo)

Mice (n=80) undergo transient middle cerebral artery occlusion (MCAo) with reperfusion after 60 minutes. After MCAo, animals are randomly assigned to receive either a daily preventive medication (n=26, Enrofloxacin) starting at the day of MCAo or a therapeutic medication (n=25; Enrofloxacin) after diagnosis of lung infection. Standard treatment started immediately after the appearance of clinical signs (general health score>6) usually between day 4 and 6 after stroke. Both, preventive and standard antibiotic treatment using Enrofloxacin improve survival in a similar way compared with placebo treatment[2].

Clinical Trial
分子量

395.86

性状

Solid

Formula

C19H23ClFN3O3

CAS 号

93106-59-3

中文名称

恩诺沙星单盐酸盐;恩罗沙星盐酸盐;恩氟沙星盐酸盐;恩氟喹啉羧酸盐酸盐;恩氟奎林羧酸盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : 7.14 mg/mL(18.04 mM;Need ultrasonic)

DMSO :< 1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble or slightly soluble)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.5261 mL12.6307 mL25.2615 mL
5 mM0.5052 mL2.5261 mL5.0523 mL
10 mM0.2526 mL1.2631 mL2.5261 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。