CAS NO: | 52152-93-9 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Cefsulodin (SCE-129) sodium is a third generation β lactamantibioticand member of the cephems subgroup ofantibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibitingpenicillin binding protein(PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potenttyrosinephosphataseinhibitor againstmPTPB, a virulentphosphatasefromMycobacterium tuberculosis, with anIC50value of 16 μM[1][2][3][4]. | ||||||||||||||||
IC50& Target |
| ||||||||||||||||
体外研究 (In Vitro) | Cefsulodin sodium (0.5-64 mg/mL; 18 h) is active in minimum inhibitory concentrations (MICs) of 0.5-64 mg/mL, is about 16- to 32-fold more active thanCarbenicillin(HY-B0525) againstPsuedomonas aeruginosa[1]. | ||||||||||||||||
体内研究 (In Vivo) | Cefsulodin sodium (1 g/kg/tag; i.p.; 5 d, 9 single doses with intervals of 12 h) shows a increasing excretion of tubule cells in the rat, as a measure of nephrotoxicity, and displays tubule toxic threshold doses of 250 mg/kg (s.c.; 12 d) with nine single doses[4].
| ||||||||||||||||
分子量 | 554.53 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C22H19N4NaO8S2 | ||||||||||||||||
CAS 号 | 52152-93-9 | ||||||||||||||||
中文名称 | 头孢磺啶钠;达克舒林;磺吡芐头孢菌素;头孢磺吡芐;头孢磺吡酮 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : 55 mg/mL(99.18 mM;Need ultrasonic) DMSO : 13.5 mg/mL(24.34 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
|