Cinoxacin

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Cinoxacin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

28657-80-9

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

西诺沙星
Compound 64716

产品介绍

Cinoxacin (Compound 64716)，一种与喹诺酮类抗生素相关的口服抗菌剂。Cinoxacin 对许多革兰氏阴性需氧菌 (Gram-negative aerobic bacteria) 具有抗菌活性，并抑制细菌 DNA 的合成。Cinoxacin 可用于尿路感染和细菌性前列腺炎的研究。

生物活性

Cinoxacin (Compound 64716), a synthetic antimicrobial related to thequinoloneclass of orally active antibacterial agent. Cinoxacin has antibacterial activity against many gram-negative aerobic bacteria and inhibitsbacterialDNA synthesis. Cinoxacin can be used for the research of urinary tract infections andbacterialprostatitis^[1]^[2].

IC₅₀& Target

Quinolone

体外研究
(In Vitro)

Cinoxacin (0-200μg/mL approximately, 3-24 h) inhibits many gram-negative aerobic bacteria with MIC values ranging from 4 to 64 μg/mL^[2].

Cell Proliferation Assay^[2]

Cell Line:	Gram-negative aerobic bacteria (Escherichia coli,Proteus sp.etc.)
Concentration:	0-200μg/mL approximately
Incubation Time:	3-24 h
Result:	Inhibited basal cell proliferation (40% in FB-2 and 35% in WRO) at 10 μM, inhibited cell number (by 68% to 73%) at 40 and 60 μM).

体内研究
(In Vivo)

Cinoxacin (Oral administration, 1.7 g/kg, treated at 1 and 5 h postinfection) is effective in experimental bacterial infections in mice, with ED₅₀values ranging from 8.1 to 58.6 mg/kg^[2].

Animal Model:	Indicated bacterial infected mice model^[2]
Dosage:	1.7 g/kg, treated at 1 and 5 h postinfection
Administration:	Oral administration
Result:	Displayed antibacterial activity with ED₅₀values ranging from 8.1 to 58.6 mg/kg.

分子量

262.22

性状

Solid

Formula

C₁₂H₁₀N₂O₅

CAS 号

28657-80-9

中文名称

西诺沙星

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 8.33 mg/mL(31.77 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.8136 mL	19.0680 mL	38.1359 mL
5 mM	0.7627 mL	3.8136 mL	7.6272 mL
10 mM	0.3814 mL	1.9068 mL	3.8136 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。