CAS NO: | 70458-95-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
100mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Pefloxacin mesylate is a an antibacterial agent and preventsbacterialDNA replication by inhibiting DNA gyrase (topoisomerse) Target: DNA gyrase Pefloxacin is a synthetic chemotherapeutic agent used to treat severe and life-threateningbacterialinfections. Pefloxacin is commonly referred to as afluoroquinolone (or quinolone) drug and is a member of the fluoroquinolone class of antibacterials. It is an analog of norfloxacin. It is a synthetic fluoroquinolone, belonging to the 3rd generation of quinolones. Pefloxacin is extensively prescribed in France. Pefloxacin has not been approved for use in the United States. The bactericidal action of pefloxacin results from interference with the activity of thebacterialenzymes DNA gyrase andtopoisomeraseIV, which are needed for the transcription and replication ofbacterialDNA. DNA gyrase appears to be the primaryquinolonetarget for gram-negative bacteria.TopoisomeraseIV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of thebacterialchromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited. | ||||||||||||||||
IC50& Target |
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分子量 | 429.46 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C18H24FN3O6S | ||||||||||||||||
CAS 号 | 70458-95-6 | ||||||||||||||||
中文名称 | 甲磺酸培氟沙星 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||||||||||
溶解性数据 | In Vitro: H2O : ≥ 100 mg/mL(232.85 mM) DMSO : 12.5 mg/mL(29.11 mM;Need ultrasonic) *"≥" means soluble, but saturation unknown. 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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