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Sitafloxacin monohydrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sitafloxacin monohydrate图片
CAS NO:163253-37-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
DU6859a monohydrate
产品介绍
Sitafloxacin (DU6859a) monohydrate 是一种有效的口服活性氟喹诺酮类抗生素。Sitafloxacin monohydrate 对广泛的革兰氏阳性和革兰氏阴性细菌 (包括厌氧菌) 以及非典型病原体具有抗菌活性。Sitafloxacin monohydrate 可用于呼吸道感染和尿路感染的研究。
生物活性

Sitafloxacin (DU6859a) monohydrate is a potent, orally active fluoroquinoloneantibiotic. Sitafloxacin monohydrate shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin monohydrate can be used for the research of respiratory tractinfectionand urinary tractinfection[1][2].

IC50& Target

Quinolone

 

体外研究
(In Vitro)

Sitafloxacin (DU6859a) monohydrate shows antibacterial activities with MIC of 0.03, 0.12, 0.06 mg/L for wild-type ATCC 49619,gyrAmutant SP39,parCmutant 1026523streptococcus pneumoniaestran, respectively[1].
Sitafloxacin (DU6859a) monohydrate shows antibacterial activities for quinolone-susceptible strains ofstreptococcus pneumoniaewith MIC of 0.03, 0.03 mg/L for EG 00093 and EG 00218 strain, respectively[1].
Sitafloxacin (DU6859a) monohydrate shows inhibition for DNA gyrase and topoisomerase IV (TopoIV) with >IC50s of 4.38, 3.12 mg/L, respectively[1].

体内研究
(In Vivo)

Sitafloxacin (DU6859a; 12.5-100 mg/kg; i.g.; daily for 4 weeks; BALB/c female mice) monohydrate has antibacterial activity.M. ulceranscells could be isolated from the inoculated footpads and there was no evidence of footpad swelling[2].

Animal Model:BALB/c female mice[2]
Dosage:12.5, 25, 50 and 100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Inhibits the growth ofMycobacterium ulceransand theM. ulceranscells.
Clinical Trial
分子量

427.83

Formula

C19H20ClF2N3O4

CAS 号

163253-37-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.