Nalidixic acid sodium salt, aquinoloneantibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit ofDNA gyraseandtopoisomeraseIVand reversibly blocks DNA replication in susceptible bacteria^[1][2].

Nalidixic acid is against a variety of microorganisms, it is against withEscherichia coli,Pasteurella spp.,Klebsiella pneuiiioniae,Aerobacter aeroyenes,Proteus spp.,Salmonella spp.,Shigella spp.andBrucella spp.with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively^[1].

The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused byE. coli,A. aerobacter,Proteus mirabilis,Shigella fkxneri, the ED₅₀values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively^[1].
The acute toxicity (LD₅₀) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg^[1].

254.22

C₁₂H₁₁N₂NaO₃

3374-05-8

萘啶酮酸

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.