| CAS NO: | 81129-83-1 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 生物活性 | Cilastatin sodium (MK0791 sodium) is a reversible, competitiverenal dehydropeptidase Iinhibitor with anIC50of 0.1 μM. Cilastatin sodium inhibits thebacterialmetallob-lactamase enzyme CphAwith anIC50of 178 μM. Cilastatin sodium is an antibacterial adjunct[1][2][3]. | ||||||||
| IC50& Target |
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| 体外研究 (In Vitro) | Cilastatin (200 μg/mL; 24 hours; RPTECs) treatment protects against Vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of Vancomycin[2]. Apoptosis Analysis[2]
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| 体内研究 (In Vivo) | In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice fromS. aureus,E. coli, andP. aeruginosainfection[3]. | ||||||||
| Clinical Trial | |||||||||
| 分子量 | 380.43 | ||||||||
| 性状 | Solid | ||||||||
| Formula | C16H25N2NaO5S | ||||||||
| CAS 号 | 81129-83-1 | ||||||||
| 中文名称 | 西司他丁钠 | ||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
| 储存方式 | 4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
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