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Cefroxadine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefroxadine图片
CAS NO:51762-05-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
CGP 9000
Oraspor
产品介绍
Cefroxadine (CGP 9000) 是一种具有口服活性的头孢类抗生素。Cefroxadine 在 106μg/mL 的浓度下,相比于头孢氨苄对大肠杆菌和克雷伯菌具有更高的活性,MIC值为 3.13 和 1.56 μg/mL。Cefroxadine 可用于感染的研究。
生物活性

Cefroxadine (CGP 9000) is an orally activecephalosporinantibiotic. Cefroxadine is more effective than cephalexin againstEscherichia coliandKlebsiella pneumoniaewithMICvalues of 3.13 and 1.56 μg/mL respectively with a concentration of 106μg/mL. Cefroxadine can be used for the research ofinfection[1].

IC50& Target

β-lactam

 

体外研究
(In Vitro)

Cefroxadine (106-108μg/mL; overnight) shows antibacterial activities againstS. aureus,E. coli,S. typhi,S. paratyphi,S. schottmuelleri,K. apneumoniaeandP. mirabiliswith MIC values of 1.56, 3.31, 1.56, 1.56, 1.56, 1.56 and 6.25 μg/mL respectively with a concentration of 106μg/mL[1]. Cefroxadine (104-108μg/mL; overnight) shows antibacterial activities against 100E. colistrains with MIC50and MIC75values of 4.8-11.5 μg/mL and 6-20 μg/mL, respectively[1].

体内研究
(In Vivo)

Cefroxadine (0-30 mg/kg; p.o. 0 and 3 h after infection) shows a better effect than cephalexin in vivo[1].

Animal Model:Mice withE. coliML4707 andK. pneumoniaeGN6445 infection[1]
Dosage:0-30 mg/kg
Administration:Oral gavage; 0-30 mg/kg; 0 and 3 h after infection
Result:Showed a better effect than cephalexin in vivo with ED50values of 21.4 and 10.9 mg/kg forE. coliML4707 andK. pneumoniaeGN6445 in vivo.
分子量

365.40

Formula

C16H19N3O5S

CAS 号

51762-05-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.