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Ciprofloxacin lactate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ciprofloxacin lactate图片
CAS NO:97867-33-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
乳酸环丙沙星
Bay-09867 lactate
产品介绍
Ciprofloxacin (Bay-09867) lactate 是一种口服有效的拓扑异构酶 IV 抑制剂。Ciprofloxacin lactate 诱导线粒体 DNA 和核 DNA 损伤并导致线粒体功能障碍和活性氧产生。Ciprofloxacin lactate 具有抗增殖活性并诱导细胞凋亡 (apoptosis)。Ciprofloxacin lactate 是一种氟喹诺酮类抗生素,具有强大的抗菌活性。
生物活性

Ciprofloxacin (Bay-09867) lactate is a potent, orally activetopoisomeraseIVinhibitor. Ciprofloxacin lactate induces mitochondrial DNA and nuclear DNA damage and lead to mitochondrial dysfunction, ROS production. Ciprofloxacin lactate has anti-proliferative activity and inducesapoptosis. Ciprofloxacin lactate is a fluoroquinoloneantibiotic, exhibiting potentantibacterialactivity[1][2][3][4].

IC50& Target

Quinolone

 

体外研究
(In Vitro)

Ciprofloxacin (Bay-09867) lactate (5-50 μg/mL; 0-24 h; tendon cells) inhibits cell proliferation and causes cell cycle arrest at the G2/M phase[1].
Ciprofloxacin (Bay-09867) lactate shows potent activity againstY. pestisandB. anthraciswith MIC90of 0.03 μg/mL and 0.12 μg/mL, respectively[2].

Cell Cycle Analysis[1]

Cell Line:Tendon cells
Concentration:5, 10, 20 and 50 μg/mL
Incubation Time:24 hours
Result:Decreased the cellularity of tendon cells.

Apoptosis Analysis[1]

Cell Line:Tendon cells
Concentration:50 μg/mL
Incubation Time:24 hours
Result:Arrested cell cycle at the G2/M phase and inhibited cell division in tendon cells.

Western Blot Analysis[1]

Cell Line:Tendon cells
Concentration:50 μg/mL
Incubation Time:0, 6, 12, 17 and 24 hours
Result:Down-regulated the expression of CDK-1 and cyclin B protein and mRNA. Up-regulated the expression of PLK-1 protein.
体内研究
(In Vivo)

Ciprofloxacin (Bay-09867) lactate (30 mg/kg; i.p.; for 24 hours; BALB/c mice) has protection againstY. pestisin murine model of pneumonic plague[3].
Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) accelerates aortic root enlargement and increases the incidence of aortic dissection and rupture by decreases LOX level and increases MMP levels and activity in the aortic wall[4].
Ciprofloxacin (Bay-09867) lactate (100 mg/kg; i.g.; daily, for 4 weeks; C57BL/6J mice) induces DNA damage and release of DNA to the cytosol, mitochondrial dysfunction, and activation of cytosolic DNA sensor signaling. Ciprofloxacin lactate increases apoptosis and necroptosis in the aortic wall[4].

Animal Model:BALB/c mice[3]
Dosage:30 mg/kg
Administration:Intraperitoneal injection; for 24 hours
Result:Reduced the lung bacterial load in murine model of pneumonic plague.
Animal Model:C57BL/6J mice[4]
Dosage:100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Had aortic destruction that was accompanied by decreased LOX expression and increased MMP expression and activity.
Animal Model:C57BL/6J mice[4]
Dosage:100 mg/kg
Administration:Oral gavage; daily, for 4 weeks
Result:Caused mitochondrial DNA and nuclear DNA damage, leading to mitochondrial dysfunction and ROS production. Increased apoptosis and necroptosis in the aortic wall.
Clinical Trial
分子量

421.42

Formula

C20H24FN3O6

CAS 号

97867-33-9

中文名称

乳酸环丙沙星

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.