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Clinafloxacin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clinafloxacin hydrochloride图片
CAS NO:105956-99-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
克林沙星盐酸盐
AM 1091 hydrochloride
CI 960 hydrochloride
PD127391 hydrochloride
产品介绍
Clinafloxacin hydrochloride (AM 1091 hydrochloride) 是一种高效广谱氟喹诺酮类抗生素 (antibiotic),对革兰氏阳性、革兰氏阴性和厌氧病原体均有抑制活性。Clinafloxacin hydrochloride 对金黄色葡萄球菌的DNA促旋酶 (DNA gyrase) 和拓扑异构酶 IV (topoisomerase IV) 有抑制作用,IC50值分别为 0.92 μg/ml 和 1.62 μg/ml。
生物活性

Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinoloneantibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro[1]. Clinafloxacin hydrochloride is againstDNA gyraseandtopoisomeraseIVof S. aureuswithIC50values of 0.92 μg/ml and 1.62 μg/ml, respectively[2].

IC50& Target

Quinolone

 

体外研究
(In Vitro)

Clinafloxacin exhibits activity againstS. pneumoniawith anMICof 1μg/ml for the parC-gyrA mutants[2].
Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of S. aureus. It against Wild typeS. aureus,gyrA mutantS. aureusandgyrA mutantS. aureuswith MIC values of 0.016 μg/ml, 0.063 μg/ml and 0.915 μg/ml, respectively[3].

体内研究
(In Vivo)

Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.
With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis[3].

分子量

402.25

Formula

C17H18Cl2FN3O3

CAS 号

105956-99-8

中文名称

克林沙星盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.