CAS NO: | 105956-99-8 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Clinafloxacin hydrochloride (AM 1091 hydrochloride) is a potent and broad-spectrum fluoroquinoloneantibiotic, has inhibitory activity against gram-positive, gram-negative bacterias, and anaerobic pathogens in vitro[1]. Clinafloxacin hydrochloride is againstDNA gyraseandtopoisomeraseIVof S. aureuswithIC50values of 0.92 μg/ml and 1.62 μg/ml, respectively[2]. | |
IC50& Target |
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体外研究 (In Vitro) | Clinafloxacin exhibits activity againstS. pneumoniawith anMICof 1μg/ml for the parC-gyrA mutants[2].Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of S. aureus. It against Wild typeS. aureus,gyrA mutantS. aureusandgyrA mutantS. aureuswith MIC values of 0.016 μg/ml, 0.063 μg/ml and 0.915 μg/ml, respectively[3]. | |
体内研究 (In Vivo) | Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model.With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis[3]. | |
分子量 | 402.25 | |
Formula | C17H18Cl2FN3O3 | |
CAS 号 | 105956-99-8 | |
中文名称 | 克林沙星盐酸盐 | |
运输条件 | Room temperature in continental US; may vary elsewhere. | |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |