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Temafloxacin hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Temafloxacin hydrochloride图片
CAS NO:105784-61-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
TMFX hydrochloride
TA-167
A-62254
产品介绍
Temafloxacin (TMFX) hydrochloride 是一种口服有效的喹诺酮类广谱抗菌剂。Temafloxacin hydrochloride 对下呼吸道和泌尿生殖道感染具有较好的耐受性。
生物活性

Temafloxacin (TMFX) hydrochloride is an orally activequinolonebroad-spectrum antibacterial agent. Temafloxacin hydrochloride is well tolerated in lower respiratory and genitourinary tract infections[1][2].

IC50& Target

Quinolone

 

体外研究
(In Vitro)

Temafloxacin hydrochloride (0-64 μg/mL; 18-24 h) shows good antibacterial activity for gram-positive/negative bacteria, with MIC ranges of<0.004-0.5, 0.5-2 and 0.06-0.25 μg/mL forE. coli,P. aeruginosa, andS. aureus, respectively[1].

Cell Viability Assay[1]

Cell Line:E. coli(16 strains),P. aeruginosa(13 strains), andS. aureus(17 strains)
Concentration:0-64 μg/mL
Incubation Time:18-24 h
Result:InhibitedE. coli(16 strains),P. aeruginosa, andS. aureuswith MIC ranges of<0.004-0.5 (MIC 90%=0.06, =0.06), 0.5-2 (MIC 90%=1, MIC 50%=1) and 0.06-0.25 μg/mL (MIC 90%=0.125, MIC 50%=0.125). MIC 90% and 50% means MIC for 90% and 50% of the isolates (unit: μg/mL).
体内研究
(In Vivo)

Temafloxacin hydrochloride (6.25, 25, 100 mg/kg; p.o.; single) shows good inhibitory activity to murine pyelonephritis[1].
Temafloxacin hydrochloride (100 mg/kg; p.o. or s.c.; single) shows rapid gastrointestinal absorption, and has excellent tissue and body fluid penetration and concentration (except for central nervous system (CNS))[1].

Animal Model:Female CF-1 mice (20-25 g) (murine pyelonephritis model)[1].
Dosage:6.25, 25, 100 mg/kg
Administration:Orally; single.
Result:Reduced the number of viable bacteria in the kidneys of mice.
Animal Model:Female CF-1 mice (20-25 g)[1].
Dosage:100 mg/kg
Administration:Subcutaneously or orally; single.
Result:1.19Pharmacokinetic Parameters of Temafloxacin hydrochloride in Female CF-1 mice[1].
Cmax(μg/mL)AUC (μg/mLoh)T1/2(h)% Urinary recovery
SC (100 mg/kg)25.286.63.425.3
PO (100 mg/kg)13.557.41.39.1
分子量

453.84

Formula

C21H19ClF3N3O3

CAS 号

105784-61-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.