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Cefmetazole
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cefmetazole图片
CAS NO:56796-20-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
头孢美唑
CS 1170
产品介绍
Cefmetazole (CS 1170) 是一种半合成的头孢霉素类抗生素 (antibiotic),具有广谱抗菌活性,包括革兰氏阳性菌、革兰氏阴性菌和厌氧菌。Cefmetazole 与青霉素结合蛋白 (PBPs) 结合,干扰细菌细胞壁的生物合成。Cefmetazole 用于妇科、腹腔、泌尿道、呼吸道、皮肤和软组织感染的研究。
生物活性

Cefmetazole (CS 1170) is a semisynthetic cephamycinantibioticwith broad-spectrum antibacterial activity, covering gram-positive, gram-negative and anaerobic bacteria. Cefmetazole binds to penicillin binding proteins (PBPs), resulting in interferingbacterialcell wall biosynthesis. Cefmetazole is used for the research of gynecologic, intraabdominal, urinary tract, respiratory tract and skin and soft tissue infections[1][2][3].

IC50& Target

β-lactam

 

体外研究
(In Vitro)

Cefmetazole (CS 1170) has antibiotic affinity toS. aureuswith a MIC value of 1.0 mg/L. Cefmetazole has affinity for PBP1, PBP2 and PBP3 with IC50values of ≤0.3, 0.109 and 0.494 mg/L[1].

体内研究
(In Vivo)

Cefmetazole (CS 1170) (100 mg/kg; i.h.; twice a day, for 7 days; male ICR mice) alters gut bacterial flora[3].

Animal Model:Male ICR mice[3]
Dosage:100 mg/kg
Administration:Subcutaneous injection; twice a day, for 7 days
Result:Reduced Peyer's patch (PP) lymphocyte cell numbers while decreased bacterial numbers in the small intestine.
Clinical Trial
分子量

471.53

Formula

C15H17N7O5S3

CAS 号

56796-20-4

中文名称

头孢美唑

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.