Tosufloxacin (A-61827) 是一种具有口服活性的氟喹诺酮类抗生素。Tosufloxacin 对革兰氏阳性和革兰氏阴性细菌表现出广泛的抗菌活性。
| 生物活性 | Tosufloxacin (A-61827) is an orally active fluoroquinoloneantibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2]. |
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体外研究
(In Vitro) | Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities againstS. aureus,Staphylococcus epidermidis,streptococci,enterococci,Bacteroides fragilis,Clostridium difficile, andClostridium perfringens[2].
Cell Viability Assay[2] | Cell Line: | S. aureus,Staphylococcus epidermidis,streptococci,enterococci,Bacteroides fragilis,Clostridium difficile, andClostridium perfringens | | Concentration: | 0.05-3.13 μg/mL | | Incubation Time: | 18 hours | | Result: | Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL forS. aureus,Staphylococcus epidermidis,streptococci, andenterococci.
Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL forBacteroides fragilis,Clostridium difficile, andClostridium perfringens, respectively. |
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体内研究
(In Vivo) | Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity againstS. aureus,E. coli, andP. aeruginosain vivo[2].
| Animal Model: | Male Slc:ICR mice infected withS. aureus[2] | | Dosage: | 1.27-2.15 mg/kg | | Administration: | Oral gavage; 1.27-2.15 mg/kg; once | | Result: | Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL. |
| Animal Model: | Male Slc:ICR mice infected withE. coli[2] | | Dosage: | 0.16-0.30 mg/kg | | Administration: | Oral gavage; 0.16-0.30 mg/kg; once | | Result: | Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.0125 μg/mL. |
| Animal Model: | Male Slc:ICR mice infected withP. aeruginosa[2] | | Dosage: | 7.66-13.39 mg/kg | | Administration: | Oral gavage; 7.66-13.39 mg/kg; once | | Result: | Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection.
Showed MIC value of 0.78 μg/mL. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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