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Antimycin A1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Antimycin A1图片
CAS NO:642-15-9
包装与价格：
包装价格(元)
500μg电议
2.5mg电议

产品介绍
Antimycin A1 是泛醇-细胞色素 c 氧化还原酶的特异性电子转移抑制剂。 Antimycin A1 通过抑制 HIF-1α 活化引起的 VEGF 产生减少来抑制血管生成。
Cas No.642-15-9
别名抗黴素A1
化学名2(or 3)-methyl-butanoic acid, (2R,3S,6S,7R,8R)-3-[[3-(formylamino)-2-hydroxybenzoyl]amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl ester
Canonical SMILESCC(C)CC(O[C@H]([C@H]1CCCCCC)[C@H](C)OC([C@@H](NC(C2=CC=CC(NC([H])=O)=C2O)=O)[C@@H](C)OC1=O)=O)=O
分子式C28H40N2O9
分子量548.6
溶解度Soluble in ethanol, methanol, DMSO, DMF
储存条件Store at -20℃, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Antimycin A, an antibiotic produced by Streptomyces species that demonstrates antifungal, insecticidal, nematocidal, and piscicidal properties, is a mixture of Antimycins A1, A2, A3, and A4. [1] It blocks mitochondrial respiration and can deplete cellular levels of ATP via inhibition of complex III of the mitochondrial electron transport chain (ETC). Antimycin A prevents the transfer of electrons between the b-cytochromes and ubiquinone at the Q(inner) site of complex III. This results in the stabilization of the ubisemiquinone radical at the Q(outer) site of complex III, leading to increased production of superoxide. [2][3] Antimycin A is widely used in research to shunt electron flow through the ETC in order to study the chemical details of oxygen respiration. Additionally, antimycin A has been shown to inhibit Bcl-2 and Bcl-xL proteins, inducing apoptosis.[3][4][5]

Reference:
[1]. Seipke, R.F., and Hutchings, M.I. The regulation and biosynthesis of antimycins. Beilstein J.Org.Chem. 9, 2556-2563 (2013).
[2]. Muller, F., Crofts, A.R., and Kramer, D.M. Multiple Q-cycle bypass reactions at the Qo site of the cytochrome bc1 complex. Biochemistry 41(25), 7866-7874 (2002).
[3]. Muller, F.L., Roberts, A.G., Bowman, M.K., et al. Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production. Biochem. 42(21), 6493-6499 (2003).
[4]. Azmi, A.S., and Mohammad, R.M. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J.Cell Physiol. 218(1), 13-21 (2009).
[5]. Marton, A., Mihalik, R., Bratincsak, A., et al. Apoptotic cell death induced by inhibitors of energy conservation--Bcl-2 inhibits apoptosis downstream of a fall of ATP level. Eur. J. Biochem. 250(2), 467-475 (1997).