ADT-OH 是一种释放硫化氢的供体。 ADT-OH 通过上调 FADD 诱导细胞凋亡并抑制体内黑色素瘤的发展。 ADT-OH具有研究癌症疾病的潜力。
| Cas No. | 18274-81-2 |
| 别名 | 5-(4-羟基苯基)-3H-1,2-二硫杂环戊烯-3-硫酮,5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione; ACS 1 |
| Canonical SMILES | OC1=CC=C(C2=CC(SS2)=S)C=C1 |
| 分子式 | C9H6OS3 |
| 分子量 | 226.3 |
| 溶解度 | DMF: 15 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 5 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. It can be readily esterified with other moieties. For example, it can be coupled with therapeutics like nonsteroidal anti-inflammatory drugs, as in the generation of ATB-343 . ADT-OH has also been linked with a mitochondria-targeting motif to produce AP-39 , which selectively increases mitochondrial H2S levels. ADT-OH is used both in cells and in animals for comparative studies with derived chimeras. |
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