NBD-14189 is a potentHIV-1entry antagonist with anIC₅₀ of 89 nM against theHIV-1_HXB2 pseudovirus. NBD-14189 binds toHIV-1 gp120and shows potent antiviral activity (EC₅₀<200 nm)^[1][2].

NBD-14189 has anti-HIV-1 activity (IC₅₀=0.089 μM) and cytotoxicity (CC₅₀=21.9 μM) in single-cycle (TZM-bl cells) assays. NBD-14189 has anti-HIV-1 activity (IC₅₀=0.18 μM) and cytotoxicity (CC₅₀=22.1 μM) in multi-cycle (MT-2 cells) assays^[1].
NBD-14189 (0-50 μM) prevents HIV-1 mediated cell-cell fusion with an IC₅₀ of 9.4 μM in indicator cells TZM-bl cells were cocultured with Env- and Tat-expressing HL2/3 cells^[1].
NBD-14189 shows weak or no inhibition of the hERG current, with an IC₅₀ of 3.0 μM, respectively^[1].

428.40

Solid

C₁₈H₁₆F₄N₄O₂S

2234273-72-2

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)