Panobinostat-d4 (hydrochloride) is deuterium labeled Panobinostat. Panobinostat (LBH589; NVP-LBH589) is a potent and orally active non-selectiveHDAC inhibitor, and has antineoplastic activities^[1][2]. Panobinostat inducesHIV-1virus production even at low concentration range 8-31 nM, stimulatesHIV-1expression in latently infected cells^[4]. Panobinostat induces cellapoptosisandautophagy. Panobinostat can be used for the study of refractory or relapsed multiple myeloma^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

389.91

C₂₁H₂₀D₄ClN₃O₂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.