TP-6076

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TP-6076

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1575495-01-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

TP-6076 是一种完全合成的氟环素类抗生素，通过与 30S 核糖体亚基结合发挥作用并维持其活性。TP-6076 显示出强大的基于机制的抗翻译活性 (抑制 Tet 蛋白翻译,IC₅₀=0.18 μg/mL)，具有广泛的抗菌和抗寄生虫活性。

生物活性

TP-6076 is a fully synthetic fluorocyclineantibiotic, acts function via binding to the 30S ribosomal subunit and maintains its activity. TP-6076 displays potent mechanism-based antitranslational activity (Tet protein,IC₅₀=0.18 μg/mL), shows a wide range of antimicrobial and antiparasitic activities^[1]^[2].

体外研究
(In Vitro)

TP-271 (0.01 ng/mL-100 μg/mL; 72 h) is active in MIC assays against key community respiratory Gram-positive and Gram-negative pathogens^[2].

Cell Viability Assay^[2]

Cell Line:	Streptococcus pneumoniae,Staphylococcus aureus,S. aureus,Streptococcus pyogenes,Haemophilus influenzae, andMoraxella catarrhalis
Concentration:	0.01 ng/mL-100 μg/mL
Incubation Time:	72 hours
Result:	Inhibited the growth ofStreptococcus pneumoniae(MIC₉₀=0.03 μg/mL), methicillin-sensitiveStaphylococcus aureus(MSSA; MIC₉₀=0.25 μg/mL), methicillin-resistantS. aureus(MRSA; MIC₉₀=0.12 μg/mL),Streptococcus pyogenes(MIC₉₀= 0.03 μg/mL),Haemophilus influenzae(MIC₉₀=0.12 μg/mL), andMoraxella catarrhalis(MIC₉₀≤0.016 μg/mL).

体内研究
(In Vivo)

TP-6076 reduces the bacterial burden in the lung in murine pneumonia models with MRSA,S. pneumoniae, andH. influenzae(1, 5, and 10 mg/kg for i.v.; 12.5, 25, 50 mg/kg for p.o.; single dose), neutropenic murineS. pneumoniaetet(M) pneumonia model (1, 5, and 10 mg/kg for i.v.; 0.3, 3, 10 mg/kg for p.o.; single dose), and immunocompetent mouseS. pneumoniaepneumonia model (30 mg/kg for p.o.; single dose)^[2].

Clinical Trial

分子量

579.56

Formula

C₂₈H₃₂F₃N₃O₇

CAS 号

1575495-01-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.