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Halofantrine hydrochloride(SKF-102886)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Halofantrine hydrochloride(SKF-102886)图片
CAS NO:36167-63-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
Halofantrine hydrochloride (SKF-102886) (SKF-102886) 是一种延迟整流钾电流的阻滞剂，通过抑制人类-ether-a-go-go-related gene (HERG) 通道和一种有效的抗疟化合物。
Cas No.36167-63-2
别名盐酸卤泛群,SKF-102886; WR-171669 hydrochloride
Canonical SMILESOC(CCN(CCCC)CCCC)C1=CC2=C(Cl)C=C(Cl)C=C2C3=CC(C(F)(F)F)=CC=C31.[H]Cl
分子式C26H31Cl3F3NO
分子量536.88
溶解度DMSO: 30 mg/mL (55.88 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Halofantrine hydrochloride (SKF-102886) is a blocker of delayed rectifier potassium current via the inhibition of human-ether-a-go-go-related gene (HERG) channel and a potent antimalarial compound[1][2].

[1]. Krishna S, et al. Pharmacokinetics, efficacy and toxicity of parenteral halofantrine in uncomplicated malaria. Br J Clin Pharmacol. 1993 Dec;36(6):585-91. [2]. Tie, H., et al., Inhibition of HERG potassium channels by the antimalarial agent halofantrine. Br. J. Pharmacol. 130, 1967-1975, (2000) Traebert.