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Pendulone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pendulone图片
CAS NO:69359-09-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
垂崖豆藤异黄烷醌
产品介绍
Pendulone 是一种异黄烷醌,具有良好的抗疟原虫活性,IC50为 7.0 μM。Pendulone 还具有抗利什曼原虫、抗菌和抗癌活性。
生物活性

Pendulone is a isoflavanquinone with good antiplasmodial activity with anIC50of 7.0 μM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2].

IC50& Target

Plasmodium

 

Leishmania

 

体外研究
(In Vitro)

Pendulone displays moderate antiproliferative activity against the A2780 human ovarian cancer cell line, with an IC50value 19.6 μM[1].
Pendulone displays an IC50value of 0.43 μg/mL, against L. donovani promastigotes. Pendulone also displays antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus (each IC50of 1.44 μg/mL)[2].
Pendulone exhibits moderate anticancer activity against human cancer cell lines (SK-MEL, KB, BT-549 and SK-OV-3) with IC50values of 5.5 and 10.5 μg/mL. Pendulone also shows moderate cytotoxicities against monkey kidney fibroblasts (VERO) and pig kidney epithelial cells (LLC-PK11)[2].
Pendulone shows strong inhibition on the effect of the cell cycle induced by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) in Raji cells[3].

体内研究
(In Vivo)

Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA[3].

分子量

316.31

Formula

C17H16O6

CAS 号

69359-09-7

中文名称

垂崖豆藤异黄烷醌

结构分类
  • Quinones
  • Benzene Quinones
  • Phenols
  • Monophenols
来源
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.