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R-Palmitoyl-(1-methyl)Ethanolamide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
R-Palmitoyl-(1-methyl)Ethanolamide图片
CAS NO:142128-47-0
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
synthetic analog of palmitoyl ethanolamide (PEA)
Cas No.142128-47-0
别名R-1 PMA
化学名N-(2-hydroxy-1R-methylethyl)-hexadecanamide
Canonical SMILESCCCCCCCCCCCCCCCC(=O)N[C@H](C)CO
分子式C19H39NO2
分子量313.5
溶解度≤10mg/ml in ethanol;25mg/ml in DMSO;3.3mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

R-Palmitoyl-(1-methyl) ethanolamide, a synthetic analog of Palmitoyl ethanolamide (PEA), incorporates the (R)-methyl group vicinal to the alcohol on the ethanolamine moiety. The analogous modification to arachidonoyl ethanolamide (AEA) protects the molecule from hydrolysis by fatty acid amide hydrolase, prolongs duration of action and enhances potency in vivo [1].

PEA is an endogenous cannabinoid existed in mammalian tissues, such as liver and brain. PEA has also been isolated from egg yolk [2, 3]. PEA is a compound with documented anti-nociceptive and anti-inflammatory effects. During inflammation, PEA is accumulated and exihibits anti-inflammatory effects, including beneficial effects in clinically relevant animal models of inflammatory pain [4].

References:
[1] Abadji V, Lin S, Taha G, et al.  (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability[J]. Journal of medicinal chemistry, 1994, 37(12): 1889-1893.
[2] Bachur N R, Masek K, Melmon K L, et al.  Fatty acid amides of ethanol-amine in mammalian tissues[J]. Journal of Biological Chemistry, 1965, 240: 1019-1024.
[3] Ganley O H, Graessle O E, Robinson H J, et al.  Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin[J]. Journal of Laboratory and Clinical Medicine, 1958, 51: 709-714.
[4] Lambert D M, Vandevoorde S, Jonsson K O, et al.  The palmitoylethanolamide family: a new class of anti-inflammatory agents [J]. Current medicinal chemistry, 2002, 9(6): 663-674.