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Warangalone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Warangalone图片
CAS NO:4449-55-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品名称
攀登鱼藤异黄酮
Scandenolone
产品介绍
Warangalone 是抗疟疾化合物,能够抑制3D7(氯喹敏感) 和K1(氯喹耐药) 寄生虫的生长,IC50值分别为 4.8 μg/mL 和 3.7 μg/mL。 Warangalone 还可以抑制环 AMP 依赖性蛋白激酶催化亚基 (cAK),其IC50值为 3.5 μM。
生物活性

Warangalone is an anti-malarial compound which can inhibit the growth of both strains ofparasite3D7(chloroquine sensitive) andK1(chloroquine resistant) withIC50s of 4.8 μg/mL and 3.7 μg/mL, respectively. Warangalone can also inhibitcyclic AMP-dependent protein kinase catalytic subunit(cAK) with anIC50of 3.5 μM.

IC50& Target

Plasmodium

 

体外研究
(In Vitro)

Warangalone is an anti-malarial compound which can inhibit the growth of both strains of parasite 3D7 (chloroquine sensitive) and K1 (chloroquine resistant) with IC50s of 4.8 μg/mL and 3.7 μg/mL, respectively[1]. Warangalone can also inhibit cyclic AMP-dependent protein kinase catalytic subunit (cAK) with an IC50of 3.5 μM[2]. When HL-60 cells are exposed to Warangalone (30 μM) for 24 h, Warangalone induces a significant decrease (8%) in cell viability compare to controls. Warangalone also inhibits HL-60 cell growth within 24 h in a time-dependent fashion. A time-dependent increase in caspase-9 activity is observed in Warangalone-treated cells[3].

分子量

404.46

性状

Solid

Formula

C25H24O5

CAS 号

4449-55-2

中文名称

攀登鱼藤异黄酮

结构分类
  • Flavonoids
  • Isoflavones
  • Phenols
  • Polyphenols
来源
  • Plants
  • Leguminosae
  • Erythrina variegataLinn.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month