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Quinine dihydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Quinine dihydrochloride图片
CAS NO:60-93-5
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
奎宁二盐酸盐
产品介绍
Quinine dihydrochloride 是一种从金鸡纳树皮中提取的生物碱，具有口服活性，可用作抗疟疾研究。Quinine dihydrochloride 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (KCa5.1) 通道 +100 mV 电流, 其IC50值为 169 μM。
生物活性

Quinine dihydrochloride is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine dihydrochloride is apotassium channelinhibitor that inhibits WT mouse Slo3 (KCa5.1) channel currents evoked by voltage pulses to +100 mV with anIC50of 169 μM[1][2].

IC50& Target

Plasmodium

 

体外研究
(In Vitro)

Quinine dihydrochloride (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line[1].
Quinine dihydrochloride (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line[1].

Cell Proliferation Assay[1]

Cell Line:Human hepatocarcinoma cell line(HepG2)
Concentration:150 μM
Incubation Time:30 min
Result:Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.
体内研究
(In Vivo)

Quinine dihydrochloride (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice[2].
Quinine dihydrochloride (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats[3].

Animal Model:Swiss albino mice 7-8-weeks (weighing 24 g)[2]
Dosage:12 mg/kg, 15 mg/kg
Administration:Oral gavage; every week; 16 weeks
Result:Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.
Clinical Trial
分子量

397.34

Formula

C20H26Cl2N2O2

CAS 号

60-93-5

中文名称

奎宁二盐酸盐

结构分类
  • Others
来源
  • Plants
  • Rubiaceae
  • Cinchona succirubraPav. ex Klotzsch
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.