L-Canaline is a nonprotein amino acid stored in many leguminousplants. L-Canaline is a cytotoxic metabolite catalyzed by L-canavanine and itsarginase. L-Canaline is a potent and irreversible inhibitor ofornithine aminotransferase. L-Canaline inhibits the growth of the malariaparasitePlasmodiumfalciparumwith anIC₅₀of 297 nM. L-Canaline has anticancer and antiproliferative effects^[1][2][3].

L-Canaline treatment inhibits the proliferation of PBMCs after stimulation by phorbol 12-myristate-13-acetate (PMA) or via the mixed lymphocyte reaction. The greatest effect is seen with PMA-stimulated cells, where L-canaline has anIC₅₀of 0.26 mM. L-Canaline is slightly less toxic to PBMCs stimulated via the mixed lymphocyte reaction (IC₅₀of 0.54 mM)^[1]. L-canaline inhibits L-lysine flux competitively (K_iof 4.6 mM) in astrocytes and astrocytoma cells^[2].

L-Canaline decreases the aspartic acid content of tissues of the medulla oblongata of male Wistar rats, but it does not affect the evoked release of this nonprotein amino acid into these tissues^[2].
Intraseptal injection of 100 μg of L-canaline into male Sprague-Dawley rats causes a 90% decrease in the omithine aminotransferase activity of the septum tissues evaluated from animals killed 1 h later^[2].

134.13

C₄H₁₀N₂O₃

496-93-5

• Amino acids

• Plants
• other families

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