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TG6-129
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TG6-129图片
CAS NO:1164464-14-5
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
TG6-129 是 EP2 受体的选择性拮抗剂。
Cas No.1164464-14-5
Canonical SMILESFC1=CC=C(/C=C/C(NC(NC2=CC=C(S(NC3=NN=C(CC)S3)(=O)=O)C=C2)=S)=O)C=C1
分子式C20H18FN5O3S3
分子量491.6
溶解度DMF: 8 mg/ml,DMSO: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Prostaglandin E2 evokes distinct responses through four different 'E prostanoid' (EP) receptors. EP2 is a G protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection. TG6-129 is an antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 µM. It is without effect on EP4, DP1, IP, and β2-adrenergic receptors. TG6-129 reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages. It has low cell cytotoxicity (CC50 = 326 µM), prolonged plasma half-life, and does not cross the blood-brain barrier.