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Polyketomycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Polyketomycin图片
CAS NO:200625-47-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Polyketomycin 是一种从链霉菌属中分离的四环醌糖苷抗生素。Polyketomycin 抑制革兰氏阳性细菌 (Gram-positive bacteria) 的生长,其 MIC 值小于 0.2 μg/mL。Polyketomycin 具有抗菌,抗癌,抗疟疾的作用。
生物活性

Polyketomycin is a tetracyclic quinone glycosideantibioticisolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth ofGram-positive bacteria, and its MIC values is less than 0.2 μg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3].

IC50& Target[1][2]

Plasmodium

 

Traditional Cytotoxic Agents

 

体外研究
(In Vitro)

Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1].

体内研究
(In Vivo)

The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1].

分子量

864.84

Formula

C44H48O18

CAS 号

200625-47-4

结构分类
  • Quinones
  • Naphthalene Quinones
  • Phenols
  • Polyphenols
来源

Streptomyces sp. MK277-AF1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.