CAS NO: | 200625-47-4 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
生物活性 | Polyketomycin is a tetracyclic quinone glycosideantibioticisolated from Streptomyces sp. or Streptomyces diastatochromogenes. Polyketomycin inhibits growth ofGram-positive bacteria, and its MIC values is less than 0.2 μg/mL. Polyketomycin has antibacterial, anticancer, antimalarial activities[1][2][3]. | ||
IC50& Target[1][2] |
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体外研究 (In Vitro) | Polyketomycin exhibits growth inhibition against L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adnocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma and B16-BL10 melanoma with IC50values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL and 1.6 μg/mL, respectively[1]. | ||
体内研究 (In Vivo) | The acute toxicity (LD50, ip) of Polyketomycin in mice is estimated to be 6.25-12.5mg/kg[1]. | ||
分子量 | 864.84 | ||
Formula | C44H48O18 | ||
CAS 号 | 200625-47-4 | ||
结构分类 |
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来源 | Streptomyces sp. MK277-AF1 | ||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |