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Pentamidine dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pentamidine dihydrochloride图片
CAS NO:50357-45-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
喷他脒二盐酸盐
MP-601205 dihydrochloride
产品介绍
Pentamidine dihydrochloride (MP-601205 dihydrochloride) 是一种抗微生物剂,会干扰 DNA 的生物合成。Pentamidine dihydrochloride 抑制寄生虫Leishmania infantumIC50为 2.5 μM。Pentamidine dihydrochloride 是一种有效的选择性蛋白酪氨酸磷酸酶 (PTPases) 和再生肝磷酸酶 (PRL) 抑制剂。Pentamidine dihydrochloride 可用于冈比亚锥虫病,抗锑利什曼病和卡氏肺孢子虫肺炎的研究。抗肿瘤活性,抗菌活性。
生物活性

Pentamidine dihydrochloride (MP-601205 dihydrochloride) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dihydrochloride inhibitsparasiteLeishmaniainfantumwith anIC50of 2.5 μM. Pentamidine dihydrochloride is a potent and selectiveprotein tyrosine phosphatases(PTPases)andphosphataseof regenerating liver (PRL)inhibitor. Pentamidine dihydrochloride has the potential forGambian trypanosomiasis, antimony-resistantleishmaniasis, andPneumocystis cariniipneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].

IC50& Target

Trypanosoma

 

Leishmania

 

体外研究
(In Vitro)

Pentamidine (0-10 μg/mL; 6 days; WM9, DU145, C4-2, Hey, WM480, and A549 cells) treatment inhibits the growth of cancer cells in a concentration-dependent manner[1].
The cytotoxic properties of Pentamidine isethionate towards the promastigotes of the protozoan parasiteLeishmania infantumis determined. The leishmanicidal activity of Pentamidine isethionate is 60 times higher after 72 h of incubation than that of Cisplatin. Pentamidine isethionate induces a higher amount of programmed cell death (PCD) than Cisplatin, which is associated with inhibition of DNA synthesis and cell-cycle arrest in the G2/M phase. Binding of Pentamidine isethionate to calf-thymus DNA (CT-DNA) induces conformational changes in the DNA double helix, consistent with a B-->A transition. The interaction of Pentamidine isethionate with ubiquitin leads to a 6% increase in the beta-sheet content of the protein[2].

Cell Viability Assay[1]

Cell Line:WM9, DU145, C4-2, Hey, WM480, and A549 cells
Concentration:0-10 μg/mL
Incubation Time:6 days
Result:The growth of all six of the cell lines in culture was inhibited in a concentration-dependent manner with complete growth inhibition of the cell lines occurring at 10 μg/mL.
体内研究
(In Vivo)

Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1].

Animal Model:Athymic nude mice (6 weeks old) injected with WM9 cells[1]
Dosage:0.25 mg/mouse
Administration:Intramuscular injection; every 2 days; for 4 weeks
Result:Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.
Clinical Trial
分子量

413.34

Formula

C19H26Cl2N4O2

CAS 号

50357-45-4

中文名称

喷他脒二盐酸盐;喷它咪二盐酸盐;戊烷脒二盐酸盐;戊脘脒二盐酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.