| CAS NO: | 209268-36-0 |
| 包装 | 价格(元) |
| 500μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 209268-36-0 |
| 别名 | 治疗哮喘药物S-5751中间体 |
| Canonical SMILES | OC(CCC/C=C\C[C@H]1C[C@@H]2C(C)(C)[C@@H](C2)[C@@H]1NC(C3=CSC4=C3C=C(O)C=C4)=O)=O |
| 分子式 | C25H31NO4S |
| 分子量 | 441.6 |
| 溶解度 | DMSO: 36 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | S-5751 is an antagonist of the prostaglandin D2 (PGD2) receptor DP1 (Ki = 1.6 nM) that shows at least 20-fold selectivity over receptors for thromboxane and prostacyclin, as well as the PGE2 receptor EP2. Orally administered S-5751 blocks PGD2-induced plasma exudation in the conjunctiva (ED50 = 0.099 mg/kg) and suppresses antigen-induced allergic responses in guinea pigs. S-5751 has been used to distinguish signaling of PGD2 through its two receptors, DP1 and DP2 (also known as CRTH2). |
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