您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > R-8507
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
R-8507
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
R-8507图片
CAS NO:338773-13-0
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).
Cas No.338773-13-0
Canonical SMILESClC(C=C1)=CC=C1C2=NN=C3N2C4=C(C=CC=C4)N=C3C(F)(F)F
分子式C16H8ClF3N4
分子量348.7
溶解度DMF: 16 mg/ml,DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml,DMSO: 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 µM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.