N-trans-Feruloyltyramine (N-feruloyltyramine) 是一种来自 Piper nigru 的生物碱，是一种 COX1 和 COX2 的抑制剂，具有潜在的抗氧化特性。
| Cas No. | 66648-43-9 |
| 别名 | N-反式-阿魏酰酪胺,N-feruloyltyramine; Moupinamide |
| Canonical SMILES | OC1=CC=C(CCNC(/C=C/C2=CC(OC)=C(O)C=C2)=O)C=C1 |
| 分子式 | C18H19NO4 |
| 分子量 | 313.4 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.33 mg/ml,Ethanol: 25 mg/ml |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | N-trans-Feruloyltyramine is a phenolic amide originally isolated from S. melongena that has diverse biological activities, including anti-inflammatory, antioxidative, and antiproliferative properties. It decreases nitric oxide (NO) production (IC50 = 17.36 µM) and inducible NO synthase (iNOS) activity and increases NO scavenging without inducing cytotoxicity in LPS-stimulated BV-2 cells. It also scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in TLC autographic and spectrophotometric assays. N-trans-Feruloyltyramine inhibits proliferation of HeLa and L929 cells by 72.2 and 22%, respectively, when used at a concentration of 30 µg/ml. |
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