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Probenecid-d14
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Probenecid-d14图片
CAS NO:1189657-87-1
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
Cas No.1189657-87-1
别名丙磺舒 d14
Canonical SMILESO=C(O)C1=CC=C(S(N(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])(=O)=O)C=C1
分子式C13H5D14NO4S
分子量299.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 10 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Probenecid-d14 is intended for use as an internal standard for the quantification of probenecid by GC- or LC-MS. Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) but activates the transient receptor potential (TRP) channel TRPV2. It inhibits OAT1, OAT3, and OAT6 with Ki values of 6.3, 9.0, and 8.4 µM, respectively, as well as OAT2 with an IC50 value of 0.67 µM. It is a poor inhibitor of the organic cation transporters OCT1 and OCT2 (IC50 = 1.6 and 1.7 mM, respectively). It also acts as an agonist of TRPV2 (EC50 = 31.9 µM), eliciting nociceptive behavior under inflammatory conditions in mice. Formulations containing probenecid have been used in the treatment of gouty arthritis.