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Memantine-d6(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Memantine-d6(hydrochloride)图片
CAS NO:1189713-18-5
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
Cas No.1189713-18-5
别名盐酸美金刚 d6 (盐酸盐)
Canonical SMILESN[C@]12C[C@](C[C@@](C([2H])([2H])[2H])(C2)C3)(C([2H])([2H])[2H])C[C@@H]3C1.Cl
分子式C12H15D6N • HCl
分子量221.8
溶解度DMSO: Soluble,Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Memantine-d6 is intended for use as an internal standard for the quantification of memantine by GC- or LC-MS. Memantine is an NMDA receptor antagonist that blocks NMDA-induced currents in rat retinal ganglion cells by 90% when used at a concentration of 12 μM. It reverses inhibition of dephosphorylation of the synthetic tau phosphopeptide p17 (tau194-207) induced by the endogenous inhibitor of protein phosphatase 2A (PP2A) I1PP2A in vitro. In vivo, memantine (2 mg/kg) restores PP2A activity, decreases GSK-3β and amyloid-β (Aβ) levels in the hippocampus, cerebral cortex, and ventricular areas, and attenuates spatial learning and memory deficits in the AAV1-I1PP2A rat model of Alzheimer's disease. Memantine (20 mg/kg) reduces responding on the ethanol-associated lever in a cue-induced ethanol-seeking test in rats. It also decreases secretion of matrix metalloproteinase-9 (MMP-9), degradation of collagen IV, the size of cerebral ischemia-induced brain infarcts, and neuronal cell death in a mouse model of focal cerebral ischemia.